Mycoplasma bovis
Morphology |
Small, pleomorphic bacterium, meaning it lacks a cell wall and can change its shape. It
is typically gram-negative and facultatively anaerobic. Due to the absence of a cell
wall, it is resistant to many antibiotics that target cell wall synthesis.
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Disease |
Chronic pneumonia, otitis, tenosynovitis and Bovine Respiratory Disease (BRD). |
Zoonosis |
None.
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Host Range |
Cattle.
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Modes of Transmission |
Close contact, aerosolized respiratory secretions, and potentially through milk.
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Signs and Symptoms |
Nasal discharge, cough, often appear depressed and may have excessive tearing. Pneumonia
(coughing, rapid breathing, fever), arthritis (lameness, swollen joints), and otitis
media (droopy ears, head tilting).
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Infectious Dose | Unknown. |
Incubation Period |
2-3 weeks.
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Prophylaxis | Minimizing stress, improving biosecurity, and potentially using vaccination. |
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Vaccines | A modified live vaccine for M. bovis: Protivity. |
Treatment |
tulathromycin, enrofloxacin, or florfenicol
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Surveillance | Monitor for symptoms. |
MSU Requirements | Report any exposures |
Laboratory Acquired Infections (LAIs) | None.
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Sources |
Cultures, frozen stocks, other samples described in IBC protocol.
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BMBL:
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https://www.cdc.gov/labs/BMBL.html |
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NIH Guidelines:
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Risk Group 2
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Agents that are associated with human disease which is rarely serious and for which preventive or therapeutic interventions are often available. |
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BSL2
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For all procedures involving suspected or known infectious specimen or cultures.
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ABSL2
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For all procedures involving infected animals
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Small
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Notify others working in the lab. Remove PPE and don new PPE. Cover area of the spill
with absorbent material and add fresh 1:10 bleach:water. Allow 20 munutes (or as directed)
of contact time. After 20 minutes, cleanup and dispose of materials.
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Large
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Mucous membrane
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Flush eyes, mouth, or nose for 5 minutes at eyewash station.
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Other Exposures
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Wash area with soap and water for 5 minutes.
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Reporting |
Immediately report incident to supervisor, complete a First Report of Injury form, and submit to Safety and Risk Management.
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Medical Follow-up
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During business hours: Bridger Occupational Health 3406 Laramie Drive. Weekdays 8am -6pm. Weekends 9am-5pm
After business hours: Bozeman Deaconess Hospital Emergency Room 915 Highland Blvd Bozeman, MT |
Disinfection |
heat, chlorine, chlorhexidine, and iodine-based disinfectants, 0.5% citric acid and
1% sodium hypochlorite
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Inactivation |
Inactivated by moist heat (60 minutes at 121oC) and dry heat (1 hour at 160-170oC).
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Survival Outside Host |
In water, it can survive for 20-60 days, while in soil, it can persist for up to 14
days in summer and 3 months in winter.
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Minimum PPE Requirements
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Lab coat, disposable gloves, safety glasses, closed toed shoes, long pants
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Additional Precautions
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Additioanl PPE may be required depending on lab specific SOPs and IBC Protocol. |